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Several subclasses of these former T-regs have been identified in the atherosclerotic lesions of mice, including Th1-Tregs (CD4 + CCR5 + IFN- + FoxP3 + T-bet + ) and T follicular helper cells (CXCR5 + PD1 + Bcl6 + CD62L lo CD44 hi CD4 + Foxp3 - ), and these have been shown to have both impaired regulatory and enhanced inflammatory function, therefore contributing to atheroprogression (91,92)

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Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies

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Therefore, it would be of interest to determine which proteins are oxidatively-modified and how the oxidized proteins correlate with the degree of tissue damage in these extra-hepatic tissues following MDMA exposure