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(2020) 11:172 doi:10.3389/fimmu.2020.00172

Through the application of PTE and Patent Term Adjustment (PTA), Novo Nordisk succeeded in pushing the expiration of the 343 patent to December 5, 2031

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As a result, kidney mitochondrial activity was affected, leading unexpectedly to a de novo rhythm in cKOt, suggesting a disruption of the renal energy homeostasis

Following 40 min of access, mice were treated as indicated (acyl-GIP at 100 nmol kg 1 , PYY at 100 nmol kg 1 (Bachem 4018880), acyl-GIP + PYY or LiCl at 0.2 M (Sigma 7447-41-8) or VEH (PBS containing 0.05% Tween80))