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Preclinical and early clinical data suggest the triple mechanism produces more pronounced metabolic effects than dual-agonist therapies

Tirzepatide studies showed only 2.4% of participants developed type 2 diabetes, compared to 13.7% taking placebo 7

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One could also speculate that increased stress hormone activity (ie, catecholamines, cortisol) in the setting of anxiety or depression could have contributed to persistent hyperglycemia

Noom is offering Metformin to eligible new members this month and plans to offer it as an upgrade to eligible Noom Weight members in Q1 2025

The new trial thus strongly reinforces the benefit of GLP-1 for heart failure with preserved ejection fraction and extends that to people with Type 2 diabetes