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Translational pharmacokinetic/pharmacodynamic model for mRNA-3927, an investigational therapeutic for the treatment of propionic acidemia

Artemisinin compounds Artemisinin is the active ingredient of the dried stems and leaves of Artemisia annua, a member of the Asteraceae family, and belongs to the sesquiterpenoids

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The maintenance and continuous renewal of IEC function is maintained by cell death of IECs, including apoptosis, necrosis, necrotizing, pyrotizing, and ferrotizing

Oral bioavailability is estimated at approximately 38%

Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury