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The SURMOUNT trials showed tirzepatide at 15 mg achieving 15% to 21% weight loss by week 72, compared to semaglutide at 2.4 mg achieving approximately 15% by week 68

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Finally, two studies reported that genetic variability in CD44 antigen might predispose patients to acetaminophen-induced liver injury at supra-therapeutic doses [106] or to acute liver failure after the drug overdose [100]

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