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The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review

Wetzler M, Talpaz M, Yee G, Stass SA, Van Etten RA, Andreeff M , Goodacre AM, Kleine HD, Mahadevia RK, Kurzrock R

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Persistent activation of the hypothalamic-pituitary-adrenal (HPA) axis, the bodys primary neuroendocrine stress-response system, has been linked to anxiety, depression, fatigue, cognitive impairment, metabolic dysfunction, cardiovascular disease, and accelerated biological aging [15]

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