Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol. 2013 May;9(5):300-6. doi: 10.1038/nchembio.1204. Epub 2013 Mar 3. PMID: 23455543; PMCID: PMC3631284
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Blocking NNMT can boost NAD productionenhancing cellular energy, improving mitochondrial function, and accelerating the breakdown of fat
As a research compound, AOD9604 UK carries a well-characterised pre-clinical and early-phase clinical research profile developed primarily through the work of Metabolic Pharmaceuticals, with published studies spanning lipid metabolism, adipose biology, 3-adrenergic receptor regulation, cartilage biology, and safety pharmacology
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