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Chronic hepatitis has not been reported as a complication of APAP overdose-associated acute liver failure.1 Poor prognostic signs include multi-organ failure, which may involve cerebral edema, renal failure, profound hypoglycemia and lactic acidosis, any signs of which should prompt an immediate liver transplant evaluation.4,6,8,50,52,53 In clinical practice, signs of unintentional toxic ingestion typically present later, when the above-mentioned complications are already apparent and have progressed

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Informed consent was obtained from a parent of each child (who also assented to study participation)

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Additionally, short study durations and standardized laboratory conditions restrict conclusions regarding long-term endocrine adaptation or translational applicability