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Participants receiving semaglutide demonstrated lower post-treatment drinking and craving scores, and while changes in overall drinking days were not observed, there was a progressive decline in heavy drinking days within the semaglutide group (Hendershot et al., 2025)
Finally, social functioning was assessed at baseline using the Social and Occupational Functioning Assessment Scale (SOFAS [46])
10.7759/cureus.77089 51 NauckM.WeinstockR
Phase III results for retatrutide are set to be released later in 2025 and in early 2026, but an earlier phase II trial recorded between a 7.2% and 17.5% reduction in body weight after 24 weeks, depending on the dose (7.2% on 1mg, 17.5% on 12mg), and up to a 24.2% reduction in body weight after 48 weeks for those on 12mg (-8.7% change for those on 1mg) 8
Nature medicine 19 , 576585, doi:10.1038/nm.3145 (2013)
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