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Boxed warning thyroid C-cell tumors: GLP-1-based medications (including semaglutide and tirzepatide) carry an FDA boxed warning for thyroid C-cell tumors observed in rodent studies

While most GLP-1-related headaches are mild and self-limiting, certain presentations require prompt medical evaluation

Participants were randomized to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

Effect of weight loss on upper airway anatomy and the apnea-hypopnea index

In vivo pharmacokinetic measurements The pharmacokinetic assessment was conducted using a total of eight male DIO C57BL/6J mice ( n = 4 per subgroup)

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