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Ongoing medical supervision and regular dose adjustments are typically required

Due to fluctuations in oestrogen (which plays a key role in preserving muscle and bone mass) levels that we see in line with menopausal changes, (peri)menopausal women are already at risk of muscle loss, and 'losing weight by whatever means could reduce bone and muscle mass further, so it is important that someone taking this medication tries to optimise their diet and physical activity levels as much as possible.' Best exercises to prevent muscle loss on GLP-1s Strength training The most effective protection is resistance and strength training, says Dr Ajaz

GLP-1RAs also reduce hepatic steatosis, circulating triacylglycerol, and low-density lipoprotein cholesterol concentrations and effectively reduce blood pressure [25]

Lenton KJ, Sane AT, Therriault H, et al

Finally, nothing in this article should be interpreted as medical guidance

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