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Secondary analysis of multiple general population studies, including AMPLITUDE-O, SELECT, ELIXA, SURPASS, and LEADER, demonstrated significant improvements in various surrogate kidney outcomes, including slowing eGFR decline, proteinuria reduction, and decreased progression to end-stage renal disease

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Adding cagrilintide, which has its own GI effects, to an aggressively-dosed retatrutide protocol without careful titration is a recipe for poor tolerance and treatment discontinuation

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