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Dermatology 5, 411422

Phenotypic shifts in keratinocytes, melanocytes, Langerhans cells, and T lymphocytes during aging are tightly linked to VDR-governed transcriptional programs and pathway crosstalk

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Notch signaling In the process of aging, the Notch signaling pathway is activated or inhibited in different tissues due to ligand-receptor imbalance, -Secretase abnormalities and downstream transcription disorders, which drive neurodegenerative diseases, cardiovascular diseases, immune senescence and metabolic disorders

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Lousse JC, Defrre S, Van Langendonckt A, Gras J, Gonzlez-Ramos R, Colette S, et al