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These dont have to be taken as frequently as oral supplements too

The regulatory machinery is completely different

Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime

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Mechanism attribution can be difficult, as increased intratumoral CD8 T cells, cytokine activation or tumor control may reflect lymph-node priming, local TME modulation, checkpoint synergy or several processes acting together