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Subsequently, selenenic acid of Sec is reduced back to selenolate by successive reactions with two molecules of GSH and forming the oxidized GSH (GSSG) as the byproduct (Fig

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Constitutively stabilized NRF2 also promotes cell proliferation, as NRF2 knockdown inhibits the proliferation of human lung cancer cell lines (Singh et al., 2008)

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Thus, YAP/TAZ could constitute a crucial molecular mechanism regulating ferroptosis in hepatocellular carcinoma cells while also promoting the emergence of sorafenib resistance [111]