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Substantial human trial data for full-length TB-4 (corneal-healing Phase 2/3 as RGN-259, plus cardiac and wound-repair programs), with clean Phase 1 safety. Cosmetic dosing is extrapolated from these programs

Excess nicotinamide is eliminated partly through a methylation pathway, meaning it consumes methyl donors in the process of excretion

Scientists study this compound to better understand cellular energy systems, fat metabolism, and enzyme activity

The compound did not advance to Phase 3 because the efficacy was insufficient for drug approval