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Elevated lactate concentrations have been demonstrated to increase the NADH/NAD+ ratio, leading to the inhibition of key glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate dehydrogenase, ultimately suppressing both glycolysis and mitochondrial respiration (85)
Westerhof and Kooyers, 2005)
The pathological examination revealed a negative surgical margin, a MIB-1 index of 10%, and marked microscopic vascular invasion (Fig
NAFLD also increases the risk of hepatocellular carcinoma (HCC) ( The prevalence of NAFLD is increasing
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Yao L, Hou J, Wu X, Lu Y, Jin Z, Yu Z, et al
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