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Specifically, E-cadherin expression was significantly decreased in the vehicle group ( Figure 5B ), while -SMA, vimentin, and type I collagen (COL1A1) expression were markedly increased ( Figures 5CE )

The study enrolled a sufficient proportion of participants who required substantial weight loss84.0% of participants in this global registration trial had a baseline BMI 35 kg/m

The results, which were published in the Lancet on Thursday, are very encouraging for the safety and efficacy of orforglipron in people with type 2 diabetes, says Daniel Drucker, an endocrinologist at the University of Toronto, adding that he is awaiting further clinical trial results of the drug in people with obesity

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