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Gender Generally, drugs-induced hepatotoxicity is more prevalent in females.89 A large retrospective study has recognized that 76% of all patients who developed severe liver failure due to drugs were females.1 No clear reason has been identified for this increased susceptibility to many different drugs in women

The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance

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Chandimali N, Bak SG, Park EH, Lim HJ, Won YS, Kim EK, Park SI, Lee SJ

doi: 10.1089/blr.2011.9814, 225

PMID 11168457