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KPV's targeted modulation of inflammation offers a different profile than blunt-force NSAIDs or steroids

The standard regimen involves: Loading doses without neurological involvement : 1 mg intramuscularly three times a week for 2 weeks [3] [8] Loading doses with neurological involvement : 1 mg intramuscularly on alternate days until no further improvement [3] [8] Maintenance therapy : 1 mg every 23 months for life in cases of pernicious anaemia or irreversible malabsorption (every 2 months if neurological involvement) [3] [8] This aggressive approach aims to prevent irreversible neurological damage, though recovery of established neuropathy may be incomplete, particularly if treatment is delayed

However, patients with irritable bowel syndrome or IBD are better off with a low-FODMAP diet, as it can exacerbate disease symptoms due to gas production and stretching of the intestinal lumen [8, 130,131,132]

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Duration of treatment should match the expected healing timeline for rib injuries

Because this combination is still investigational, exact dosing is managed within the trial protocol