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However, starting with an SGLT2 inhibitor or a GLP-1 RA in an individual who is intolerant to metformin (primarily diarrhea) is a good choice, and even in the future we may see large diabetes organizations recommending these two classes as first line therapy once they get less expensive.

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FDA Drug Approval Database (Tesamorelin)

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"The structure and function of the eukaryotic ribosome"

Mahajan S, Koranne R, Sharma S