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Bristol: Journal of Endocrinology Ltd

Many patients achieve remission or low disease state, which can be attributed to the development of specific DMARDs

30,37 They are corticosteroid-sparing agents that are thought to reduce T-cell function

They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

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