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Previous studies also found that the circulating levels of corticosterone, thyroid hormone and testosterone of male Glp1r / mice were similar to those in the control mice, indicating that the hypothalamic-pituitary-gonadal axis has not been greatly affected by GLP-1 signaling [51]

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In 17,604 adults with overweight or obesity and established cardiovascular disease but no diabetes, semaglutide 2.4 mg cut the risk of major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) by 20 percent over a mean follow-up of 39.8 months [9]

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