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In rat studies, BPC-157 applied immediately after sciatic nerve injury significantly improved the healing process, accelerating axonal regeneration, increasing motor action potentials, and improving functional recovery

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Besides, berberine can prevent NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome from being activated during the inflammation process of Parkinsons disease and restore autophagy activity to protect dopamine neurons ( In addition to the above studies, in the zebrafish Parkinsons disease model, berberine derivatives can be used to treat Parkinsons disease