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10.1161/ATVBAHA.108.162073 Summary Keywords DPP-4, DPP-4i, GLP-1, inflammation, cardiovascular effects, hypertension Citation Zhang J, Chen Q, Zhong J, Liu C, Zheng B and Gong Q (2019) DPP-4 Inhibitors as Potential Candidates for Antihypertensive Therapy: Improving Vascular Inflammation and Assisting the Action of Traditional Antihypertensive Drugs

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By reducing the volume of blood pooling in the legs, Pycnogenol can help to lower the compensatory rapid heart rate (tachycardia) that POTS patients experience upon standing, thereby improving orthostatic tolerance and reducing episodes of dizziness and pre-syncope