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While all of the CYP enzymes discussed are involved in statin metabolism, it is likely that genetic variations in enzymes with major metabolism roles have a significant effect on statin disposition

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[DOI] [PMC free article] [PubMed] 171.Wu F., Koenig K.L., Zeleniuch-Jacquotte A., Jonas S., Afanasyeva Y., Wjcik O.P., Costa M., Chen Y

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Similarly, NEK7 is glutathionylated at Cys253 and requires GSTO1-dependent deSSG to interact efficiently with NLRP3 67