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In fibrotic lung tissue, TGF-1 expression is markedly elevated and contributes to the activation of fibroblasts into MYFs, increased synthesis of fibronectin, type I collagen, and -SMA, as well as promotion of EMT through canonical Smad-dependent signaling and non-canonical pathways [120, 121]

While the product is well tolerated in cattle, there is a risk of human injury associated with accidental self-injection