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The melanocortin system, a network of hormonal and neuropeptidergic pathways, plays a crucial role in various physiological processes

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Furthermore, NO appears to influence protein kinase B (Akt) signaling though a cGMP/phosphoinositide 3-kinase- (PI3K) dependent pathway [8], which is the primary pathway for up-regulating translation initiation required for muscle protein synthesis (MPS)

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It has been shown that KD may have anti-tumor potential for several cancer types, including colorectal, brain, breast, and pancreatic cancer (221)