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doi: 10.1021/AM502537K 116 MihajlovicM.LazaridisT

Mitochondria contain 1015% of cellular GSH, but being of a very small volume, the local concentration of GSH in these organelles is generally great and 8590% in the cytosol

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125 Moreover, research indicates that growth hormone enhances CYP3A4 expression in human hepatocytes, while synthetic somatostatin analogs like octreotide, which inhibit endogenous growth hormone, may decrease CYP3A4 activity