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Suppl.,2006, 5(4), 418-429 9

Targeting ferroptosis as a cell death pathway in melanoma: From molecular mechanisms to skin cancer treatment

Quercetin and other flavonoids are known to behave as mild prooxidants resulting in the upregulation of protective genes, such antioxidant enzymes, glutathione, and cytoprotective enzyme Heme Oxygenase HO-1 mediated by activation of the Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor upregulating antioxidant response, expression of antioxidant enzymes, and cytoprotective proteins (Ma and He 2012)

10.1016/j.intimp.2017.03.029 82 WangP.LiuX.SongY.LiuX.WangX.ZhuK.et al (2025)

doi: 10.1158/1078-0432.CCR-14-2437 57

Properly interpreting results requires skilled interpretation of the individuals medical history and underlying health conditions