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animal reproductive studies have not been conducted

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Acute maternal pretreatment with the NKCC1 antagonist bumetanide was able to restore the excitation-inhibition switch in neonatal Fmr1 knockout mice and correct electrophysiological and behavioral phenotypes (72)

These pathological changes may manifest as cognitive impairment, sensory deficits, and motor dysfunction in patients undergoing paclitaxel-based chemotherapy

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