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Acknowledgments We thank the members of Chan Lab for critical comments on this manuscript

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Research Use Only These studies reference research-grade peptides for laboratory and scientific investigation only

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This co-expression indicates a mechanism within the CNS allowing these neurons to sense and respond to the peripheral inflammatory state

Certain findings indicate that DSIP may initially cause arousal in the early stages of rest followed by sedative effects later, suggesting a possible role in balancing or stabilizing disrupted sleep cycles