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In the landmark 68-week STEP-1 trial, adults with overweight or obesity who reached the 2.4 mg maintenance dose lost roughly 15% of their body weight on average a magnitude that had previously belonged to bariatric surgery, not an injection

Following the ligand binding, the activated IGF-1 or insulin receptor starts the phosphorylation of numerous intracellular substrates

stop use if you develop swelling, hives, persistent burning, or worsening redness

If a single class of medications can meaningfully address both metabolic and addictive disorders, it challenges us to rethink the boundaries between these fields

Dekker I, van der Leest M, van Rijk MC, Gerritsen WR, Arens AIJ

So, that's why we're just sort of tactically negative those technicals are very strong in an environment where there really has not been much supply