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6 suggests that two substitutions (N74S and R121S) give rise to structural changes that reorient the copper-coordinating side chains of H451 and H453

This innovation allowed clinicians to evaluate patients' pharmacological treatment plans and implement individualized therapies, thereby enabling more targeted medical monitoring

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Begin CLA at a lower fraction of the commonly studied dose and gradually increase toward 3.2 grams per day if metabolic markers remain stable