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In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig

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People who have diabetes and cardiovascular disease should also consider the use of a sodium-glucose cotransporter 2 (SGLT2) inhibitor, as this class of medication has also shown benefit in individuals with preexisting cardiovascular disease and type 2 diabetes, Dr

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