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PLoS ONE 12 , e0178525 (2017)

Biomarkers such as CYP370A13 expression, glutathione depletion, and oxidative stress serve as sensitive indicators of APAP exposure

However, the exact contribution strongly depends on muscle type and animal species

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[37] [38] Chronic consumption of paracetamol is in many cases not of benefit, [25] and may result in abnormal liver function tests, and higher doses may lead to toxicity, including liver failure