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While the ATF4 pathway is not discussed in this report, it is frequently activated downstream of UPR

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Its core symptoms (extenuating fatigue, post exertional exacerbation, cognitive dysfunction, sleep disorders and pain) are shared with the other PAIS ( Table 1 , which will be described later, the term ME/CFS will point to long diseases in which the triggering pathogen is neither SARS-CoV-2 nor Borrelia (otherwise, they would be called long COVID or long Lyme)