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J Clin Pharm Ther 45(Suppl 1):4360

Additionally, GLP-1 receptors are widely expressed in the heart and therefore studies have shown that the benefits exceed glucose control and are also helpful in the cardiovascular system

In SURMOUNT-2, the mean WL was up to 15.7% with tirzepatide 15 mg compared to 3.3% WL with placebo at 72 weeks for people with obesity and T2D [47]

FDA-Approved Weight Loss Medications Overview The FDA has approved several medications specifically for chronic weight management, but they vary dramatically in effectiveness

However, prolonged exposure to GLP-1RAs can lead to tachyphylaxis, reducing their effect on gastric emptying over time

Ultimately, our goal is not to find one medication that works for everyone