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(1992, Biochem J) demonstrated that IGF-1 and its variants including Long R3 IGF-1 are anabolic in dexamethasone-treated rats, confirming the utility of IGF-1 LR3 in models of catabolic states and muscle wasting where native IGF-1 activity is suppressed by glucocorticoid-driven IGFBP upregulation

Short-Term Very Low Calorie Diets (VLCD) : In select cases, rapid weight loss using diet alone may be feasible with clinical oversight

doi: 10.3389/fcimb.2022.1031814 26 d'EnfertC.KauneA

However, a small percentage of patients discontinue treatment specifically due to persistent or severe gastrointestinal side effects

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They may have diabetes, dyslipidemia, or high blood pressure, so they are on multiple drugs