03 Competitive Pricing Structure: Direct manufacturer pricing with transparent profit margins (10-30%) enables cost-effective procurement for bulk purchasing requirements
PLOS ONE , 5(9), e12684
It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
Most people find this to be uncomfortable, but not unbearable, and it dramatically impacts the results you get - so its a tradeoff most people are willing to make
Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance
However, many people struggle to get enough, especially those with dietary restrictions, certain medical conditions, or absorption issues