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doi: 10.1146/annurev.pathol.4.110807.092314 2

Finally, the amino acid cysteine (Cys) at position twenty-seven is replaced with a modified amino acid called N-methylglycine (Sar)

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This mechanical effect synergistically combines with the endothelial weakening and the general procoagulanttill the generation of microthrombiinduced by dysfunctional visceral adiposity (Table 3) [173,174,175,176,177,178,179,180]