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Actuaries should monitor differential uptake, adherence, and downstream outcomes across demographic and clinical segments to avoid hidden selection effects

Self-funded plans (where the employer assumes financial risk and UnitedHealthcare administers claims) have higher exclusion rates for weight-loss GLP-1s because cost-conscious employers specifically exclude high-cost obesity drugs

Another review study looked at ALA's effects on people with several metabolic diseases, including type 2 diabetes

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Table 2 Oncogenes and tumor suppressor genes regulate tumor Gln metabolism

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