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As their use has expanded dramatically in recent years, questions about long-term safety, including potential cancer risk, have become increasingly important for both patients and clinicians

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The most common effects are mild injection site reactions (temporary redness or slight discomfort), occasional mild water retention (often temporary and dose-dependent), rare reports of mild tingling or numbness in extremities (usually transient), mild increases in hunger in some subjects (less common than with GHRP-6), and occasional mild headaches (often resolve quickly)

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Insulin, induced by feeding, stimulates TGF-1 expression in adipocytes, activating the TGF--SMAD3 pathway