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Some patients experience reduced blood flow to extremities as the body prioritizes core organ function during the weight-loss phase

Compounded semaglutide and tirzepatide contain the same active ingredients that produced 15 to 22% body weight loss in clinical trials

This difference is probably the result of an increase in adipose tissue volume, which plays a crucial role in the pathomechanism of IR

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Paper: biorxiv.org/content/10.110 #PeptideDesign #AI #ProteinMPNN #GLP1RA #Diabetes #Obesity #Pharmacokinetics #ComputationalBiology #Biotechnology AI-Driven Efficient De Novo design of GLP-1RAs with Extended Half-Life and Enhanced Efficacy 1