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Questions a doctor wants you to ask first Who GLP-1 medications are really for, what happens if you stop, and the red flags to watch for, according to a triple board-certified obesity medicine physician Please note: This article is based on an exclusive interview with Oluwatosin Ajao, MD, a triple board-certified physician in internal medicine, obesity medicine, and lifestyle medicine, known to her patients as Dr

Diabetologia 51 , 15521553 (2008)

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What the new mechanism is: GLP-1 : appetite regulation, improved glucose control GIP : incretin effects that may augment metabolic benefits Glucagon receptor activity : potentially influences energy expenditure and fat metabolism (while requiring careful balancing of tolerability and metabolic effects) What results look like (so far): Phase 2 (48 weeks) published in NEJM showed substantial mean weight reductions (with higher doses showing very large effects)