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Proliferation: Significantly increases Ki-67 expression, signaling senescent cells to re-enter the cell cycle

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The researchers examined the impact of these interventions through a biochemical characterization of brain homogenates, quantifying oxidative and inflammatory markers such as lipid peroxides, glutathione (GSH), glutathione S-transferase (GST), 5-lipoxygenase (5-LOX), cyclooxygenase-2 (COX-2), leukotriene B4, prostaglandin E2, and ascorbic acid using spectrophotometric assays and ELISA

Wild-type p53 can inhibit cancer occurrence through inhibition of the mevalonate pathway

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Besides, Akt phosphorylates and inactivates GSK3, FOXO, and TSC1/2, leading to activation of Wnt signaling, inhibition of apoptosis, and activation of mTORC1, respectively [47]