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Activation of LDHA by oncogenic receptor tyrosine kinase FGFR1 promotes glycolysis and tumor growth by increasing the NAD + /NADH ratio, 368 while the aberration of NAD + /NADH due to reduced activity of mitochondrial complex I promotes the aggressiveness of human breast cancer cells

This enhanced glucose disposal improves both fasting and post-meal blood sugar control over time

Monitoring these changes can help ensure that they are not related to an underlying health issue