Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
Discomfort tends to be minimal and short-lived
Vrionedes Today If youve been affected by troubling visual symptoms after using Ozempic or Wegovy, your choices now go beyond treatment
35 A relatively small open-label study on eight patients with diabetes mellitus and biopsy-proven NASH found that 28 weeks of exenatide treatment made no significant difference in liver histology, and only three of the eight subjects did meet the primary end point of improved histopathology, with 1 to 2 point fibrosis improvement seen in four subjects and fibrosis worsening by 1 point in one subject and staying the same in three subjects
The modest increases in response rate observed later in treatment were unexpected and may reflect enhanced task engagement following extended sucrose deprivation during the testing phase, when daily training and sucrose access were paused, rather than drug-induced activation
In one study, participants who followed an exercise programme maintained their weight even a year after the programme ended, while those who relied on medication alone were more likely to regain weight.[8] Current guidance from the World Health Organisation recommends aiming for at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity physical activity per week, plus two sessions of muscle-strengthening exercises.[9] Research shows that people who receive continued professional support after losing weight are more likely to maintain their results long-term.[10] When you come off GLP-1 medication, appetite, routine and motivation can all begin to shift, and working with a healthcare professional, dietitian or fitness specialist can help you navigate this transition
