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Dehydration from gastrointestinal side effects, as noted in FDA Medication Guides, may contribute substantially to headache development, especially during the initial treatment period when these effects are most pronounced

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It is better described as a natural metabolic support than a natural version of a weight-loss drug

Consequently, the 2024 American Gastroenterology Association (AGA) Rapid Clinical Practice Update recommends that management should depend on upper gastrointestinal symptoms

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