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Exenatide (Byetta/Bydureon) was the first GLP-1 receptor agonist to reach the market (FDA 2005), derived from the venom peptide exendin-4 found in the Gila monster lizard

A similar dynamics was observed in grk2 mutants (although the effect was less prominent), and in some of the eat16 and osm6 mutants (though not as consistent as observed in the tax6 mutant animals, Fig 3A and D and Appendix Fig S3E and I)

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D-DW built the model, evaluated the data, and wrote the manuscript

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With respect to glutathione S-transferases, they catalyze the conjugation of reduced glutathione to diverse compounds, enabling the detoxification of xenobiotic-derived substances, yet they can also activate oxidative metabolites with carcinogenic potential